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The medical use of notoginseng

2023-02-03

anti-inflammatory
PNS has a significant inhibitory effect on the increase of capillary permeability caused by histamine, acetic acid, xylene, 5-hydroxytryptamine and bradykinin. It has a significant inhibitory effect on rat paw swelling caused by egg white, formaldehyde, dextran, 5-hydroxytryptamine and carrageenan, and mouse ear swelling caused by croton oil and xylene. It also has obvious inhibitory effect on the formation of cotton ball granuloma in rats.

The main active ingredient of anti-inflammatory is saponin, mainly ginseng diol saponin.

The anti-inflammatory effect has a certain relationship with the pituitary-adrenal system. PNS can reduce the vitamin C content in the adrenal gland of rats. Intraperitoneal injection of PNS in guinea pigs can increase the concentration of corticosteroids in plasma. However, it still has obvious anti-inflammatory effect on rats with adrenal gland removed, indicating that the anti-inflammatory effect of PNS is not completely dependent on the pituitary-adrenal system. the

Liver protection
Panax notoginseng has anti-liver damage effect. PNS can significantly reduce serum ALT activity in mice with CCl4 liver injury. Methanol extract can significantly reduce the activity of AST and lactate dehydrogenase (LDH) in the serum of rats to CCl4, D-galactosamine-induced liver injury in rats, and reduce the degeneration and necrosis of liver cells. Panax notoginseng also has anti-hepatic fibrosis effect. For rats with liver injury caused by dimethylnitrosamine poisoning, treatment with panax notoginseng powder for 4 weeks can reduce the degeneration and necrosis of liver cells and reduce the collagen fibers between liver cells. For rats with hepatic fibrosis caused by CCl4 poisoning, taking Sanqi powder orally for 9 weeks while modeling CCl4 can reduce hepatic fatty degeneration, inflammatory cell infiltration, and hepatic cell degeneration and necrosis. Reduces proliferation of fibroblasts and collagen. Panax notoginseng has a certain choleretic effect, and Sanqi injection can significantly reduce serum bilirubin and promote bile secretion in rabbits with intrahepatic obstructive jaundice caused by a-naphthyl isothiocyanate. Panax notoginseng promotes liver protein synthesis, increases the incorporation rate of 3H-TdR into damaged liver DNA, and increases the incorporation rate of 3H-leucine into liver protein. the

Antitumor
Ginsenoside Rh1 has inhibitory effect on isolated liver cancer cells. Ginsenoside Rh can inhibit the growth of mouse melanoma (B16) in a concentration-dependent manner. When notoginseng saponin exists with concanavalin (ConA) or phytohemagglutinin (PHA), the mouse splenocytes induced by it have strong anti-tumor activity, which may be due to PNS enhancing the killing of activated immune cells ability. the

analgesia
Radix Notoginseng is a commonly used medicine for treating bruises and has definite analgesic effect. It has analgesic effect on various pain models such as mouse writhing method, hot plate method and rat optical radiation tail flick method. The analgesic active ingredient is ginseng diol saponin.

The core health functions of notoginseng:

1. Dilate blood vessels, lower blood pressure, improve microcirculation, increase blood flow, prevent and treat heart and brain tissue ischemia and hypoxia;

2. Promote the synthesis of protein, ribonucleic acid (RNA), and deoxyribonucleic acid (DNA), and strengthen the body;

3. Promote the metabolism of blood cells, balance and regulate blood cells;

4. Two-way regulation of central nervous system, improve brain power, enhance learning and memory ability;

5. Enhance the body's immune function and anti-tumor;

6. Stop bleeding, promote blood circulation and remove blood stasis;

7. Liver protection and anti-inflammation;

8. Delay aging;

9. Two-way regulation of blood sugar, lower blood lipids, cholesterol, inhibit arteriosclerosis

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