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Can licorice root be used topically for skin conditions or wound healing?


Licorice root (Glycyrrhiza glabra) has been utilized in traditional medicine for its diverse medicinal properties, including its anti-inflammatory, antimicrobial, and wound-healing effects. In recent years, there has been growing interest in exploring the therapeutic potential of licorice root when applied topically for various skin conditions and wound healing. This article aims to provide a comprehensive analysis of the benefits and scientific evidence supporting the use of topical licorice root in dermatology, discussing its potential applications and safety considerations.

Anti-Inflammatory and Antioxidant Properties:
Licorice root contains various bioactive compounds, such as glycyrrhizin, glabridin, and liquiritin, which possess potent anti-inflammatory and antioxidant properties. Topical application of licorice root can help reduce skin inflammation associated with conditions like eczema, psoriasis, and dermatitis. Additionally, its antioxidant activity may protect the skin from oxidative stress and premature aging caused by free radicals.

Management of Hyperpigmentation:
Glabridin, a key compound in licorice root, has been shown to inhibit the enzyme tyrosinase, responsible for melanin production in the skin. This property makes licorice root an effective agent in managing hyperpigmentation, such as melasma and age spots. Topical formulations containing licorice root extract or glabridin have shown promising results in reducing the appearance of dark spots and evening out skin tone.

Antimicrobial and Wound-Healing Effects:
Licorice root's antimicrobial activity makes it suitable for topical applications in wound healing and addressing skin infections. Studies have demonstrated its effectiveness against a range of bacteria, fungi, and viruses, which may help prevent infection and promote faster wound healing. The presence of anti-inflammatory compounds in licorice root can also aid in reducing inflammation and facilitating tissue repair.

Moisturizing and Soothing Properties:
Licorice root contains mucilage, a natural compound that provides moisturizing and soothing effects when applied topically. This makes it beneficial for dry, irritated, or sensitive skin conditions. Licorice root can help retain moisture and form a protective barrier on the skin, which may alleviate symptoms of dryness, redness, and itching.

Potential Application in Acne Treatment:
Due to its anti-inflammatory, antimicrobial, and sebum-regulating properties, licorice root has been explored as a potential adjunct therapy for acne management. Topical formulations containing licorice root extract have shown promise in reducing acne lesions, controlling inflammation, and preventing bacterial colonization of the skin.

Safety Considerations:
While topical use of licorice root is generally considered safe for most individuals, some precautions should be taken. Individuals with a history of hypersensitivity to licorice or its components may experience skin irritation or allergic reactions. It is advisable to conduct a patch test before applying licorice root topically on a larger area to check for any adverse reactions. Pregnant or breastfeeding individuals should consult with their healthcare provider before using licorice root topically.

Formulation Considerations:
When incorporating licorice root into topical formulations, factors such as extraction methods, concentration, and formulation compatibility should be considered. Extracts with higher concentrations of active compounds, such as glabridin or liquiritin, may be more effective for specific skin conditions. Choosing suitable base formulations, such as creams, ointments, gels, or serums, is crucial to optimize the delivery and absorption of licorice root's beneficial compounds into the skin.

Clinical Evidence and Future Research:
While numerous studies and anecdotal evidence support the use of topical licorice root for various skin conditions, further well-designed clinical trials are needed to establish its efficacy and safety conclusively. Collaborative efforts among researchers, dermatologists, and herbalists are essential to explore the full potential of licorice root in dermatology.


Topical licorice root holds significant promise as a natural remedy for various skin conditions and wound healing. Its anti-inflammatory, antimicrobial, and antioxidant properties make it a valuable ingredient in dermatology formulations. Licorice root can potentially help manage hyperpigmentation, soothe skin irritation, promote wound healing, and provide adjunct therapy for acne. While generally safe for topical use, individuals with known hypersensitivity to licorice root should exercise caution and conduct a patch test before application. To fully harness the therapeutic potential of licorice root in dermatology, further clinical research is necessary. By combining traditional knowledge with evidence-based practices, topical licorice root can become a valuable addition to dermatological treatments, offering natural and effective solutions for various skin conditions and wound care.

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