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Are there any known interactions between licorice root and hormonal medications or contraceptives?


Licorice root (Glycyrrhiza glabra) is a popular herbal remedy known for its sweet taste and numerous health benefits. However, it contains active compounds, primarily glycyrrhizin, which may interact with hormonal medications and contraceptives. These interactions can have significant implications for individuals using licorice root and may impact the effectiveness and safety of hormonal treatments. In this article, we will explore the potential interactions between licorice root and hormonal medications or contraceptives, providing important insights for both healthcare practitioners and patients.

The Active Compound in Licorice Root: Glycyrrhizin
Glycyrrhizin is the primary active compound in licorice root responsible for its characteristic sweetness. It exhibits various pharmacological effects, including anti-inflammatory, immunomodulatory, and antiviral properties. However, glycyrrhizin also has the potential to affect hormonal regulation in the body, specifically by inhibiting the enzyme 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2).

Glycyrrhizin and Cortisol Metabolism
Cortisol, a hormone produced by the adrenal glands, plays a vital role in regulating the body's stress response and various physiological functions. 11β-HSD2 is an enzyme that inactivates cortisol in certain tissues, preventing excessive cortisol levels. Glycyrrhizin inhibits this enzyme, leading to increased cortisol activity in these tissues.

Interactions with Hormonal Medications:
3.1 Corticosteroids:
Glycyrrhizin's interference with cortisol metabolism may lead to decreased effectiveness of corticosteroid medications, which are synthetic versions of cortisol. This could result in reduced therapeutic effects and potential treatment failure for conditions like asthma, rheumatoid arthritis, and inflammatory disorders.

3.2 Oral Contraceptives:
Licorice root may interact with oral contraceptives, affecting hormonal levels and potentially compromising contraceptive efficacy. Women using hormonal contraceptives should be cautious when consuming licorice root in large quantities or for extended periods.

3.3 Hormone Replacement Therapy (HRT):
Glycyrrhizin's impact on cortisol metabolism may also interfere with hormone replacement therapy for menopause, potentially affecting the balance of hormones and leading to adverse effects.

Estrogenic Effects of Licorice Root:
Apart from its impact on cortisol metabolism, licorice root has been found to possess weak estrogenic effects. This could be attributed to the presence of phytoestrogens, which are plant-derived compounds that can mimic estrogen in the body. These estrogen-like effects may be concerning for individuals with estrogen-sensitive conditions, such as certain types of breast cancer.

Health Conditions Potentially Affected by Licorice Root:
5.1 Hypertension:
Glycyrrhizin's ability to cause sodium retention and potassium loss may lead to an increase in blood pressure. Individuals with hypertension should avoid excessive licorice root consumption, especially in extract form.

5.2 Cardiovascular Conditions:
Patients with heart conditions or a history of cardiac issues should use licorice root with caution due to its potential impact on blood pressure and electrolyte balance.

5.3 Diabetes:
Licorice root's influence on cortisol metabolism may affect blood sugar levels, potentially complicating diabetes management. Diabetic individuals should monitor their blood glucose levels carefully when using licorice root.

Recommendations and Precautions:
6.1 Consult a Healthcare Practitioner:
Individuals taking hormonal medications or contraceptives should consult their healthcare practitioner before using licorice root or any other herbal supplements. This is especially crucial for pregnant and breastfeeding women and those with pre-existing health conditions.

6.2 Limit Licorice Root Consumption:
To reduce the risk of interactions, patients on hormonal medications should limit licorice root intake and avoid concentrated extracts. Occasional use in culinary applications or herbal teas may be safer than prolonged or high-dose supplementation.

6.3 Monitor Blood Pressure and Hormonal Levels:
Patients using licorice root should undergo regular monitoring of blood pressure and hormonal levels to detect any potential alterations and address any adverse effects promptly.

6.4 Consider Alternative Herbs:
In cases where licorice root is contraindicated, healthcare practitioners may recommend alternative herbal remedies with similar therapeutic effects but without the risk of hormonal interactions.


Licorice root, with its potent active compound glycyrrhizin, has the potential to interact with hormonal medications and contraceptives, affecting cortisol metabolism and possibly interfering with hormonal balance. These interactions could compromise the efficacy and safety of hormonal treatments, leading to treatment failures or adverse effects. It is essential for healthcare practitioners and patients to be aware of these potential interactions and exercise caution when using licorice root, especially in concentrated extract form. Open communication between patients and healthcare providers is vital to ensure safe and effective herbal supplement use in conjunction with hormonal medications or contraceptives.

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